Anti-ALOX5AP Antibody

This polyclonal IgG antibody from Antibodies.com is raised in rabbit and specifically recognizes human ALOX5AP (arachidonate 5-lipoxygenase activating protein), the integral membrane protein also referred to as FLAP that is required for leukotriene biosynthesis through the 5-lipoxygenase pathway. The unconjugated reagent is supplied as 50 µl of liquid and is validated for Western blot detection of the target in human-derived samples. ALOX5AP functions as an essential scaffold that presents arachidonic acid to 5-lipoxygenase at the nuclear envelope, coupling enzyme activation with the production of leukotriene A4 and downstream lipid mediators that drive inflammatory signaling. Because of its central role in leukotriene synthesis, ALOX5AP is widely investigated in studies of atherosclerosis, myocardial infarction risk, ischemic stroke, bronchial asthma, and other chronic inflammatory disorders where altered leukotriene output is implicated. Researchers using this antibody can probe ALOX5AP expression in cell lysates and tissue homogenates to characterize pathway activity, evaluate pharmacological inhibition by FLAP inhibitors, or stratify patient samples in cardiovascular and respiratory research programs. For best results, store the antibody frozen at -20 °C in working aliquots to limit freeze-thaw cycles, and follow standard Western blot protocols with appropriate blocking and detection reagents suitable for a rabbit primary antibody.