Anti-ALDH8A1 Antibody

The polyclonal antibody from Antibodies.com targets ALDH8A1 (aldehyde dehydrogenase 8 family member A1), an enzyme involved in cellular aldehyde detoxification and the metabolism of 9-cis-retinal. Raised in rabbit and supplied as an unconjugated reagent at 100 µl, the antibody is validated for Western blot and immunohistochemistry workflows and cross-reacts with both human and mouse samples.

ALDH8A1 catalyzes the NAD-dependent oxidation of aldehydes to their corresponding carboxylic acids, playing a recognized role in protecting tissues from aldehydes generated during lipid peroxidation and oxidative stress. Researchers studying alcohol metabolism, retinoid signaling pathways, hepatic detoxification mechanisms, and aldehyde-related toxicity in mammalian systems frequently use this reagent to probe ALDH8A1 protein expression across cell and tissue contexts. IHC support makes it useful for examining protein distribution in fixed tissue sections, while WB enables size and expression-level confirmation in lysates prepared from cultured cells or tissue.

The polyclonal format offers broader epitope coverage than monoclonal alternatives, which can be valuable when probing proteins with limited immunogenic regions or when tracking expression across isoforms. For short-term use, keep the vial refrigerated and protected from light; avoid repeated freeze-thaw cycles to preserve antibody activity and binding performance.