Anti-ALDH6A1 Antibody

ALDH6A1 (aldehyde dehydrogenase 6 family member A1) is a mitochondrial enzyme that catalyzes the oxidative decarboxylation of methylmalonate semialdehyde and malonate semialdehyde, steps that sit on the valine and pyrimidine catabolic pathways. The unconjugated rabbit polyclonal antibody distributed by Antibodies.com was raised against the human ALDH6A1 protein and is validated for western blot and immunohistochemistry workflows on human specimens.

The reagent is supplied as a 100 µl liquid aliquot of affinity-purified IgG in a buffer formulated for direct dilution into standard immunoblotting and IHC protocols. Investigators studying inborn errors of metabolism, in particular methylmalonic aciduria linked to ALDH6A1 deficiency, apply this reagent to probe mitochondrial fractions, patient-derived fibroblasts, and fixed tissue sections for loss-of-function phenotypes. The polyclonal format offers broad epitope coverage, useful when validating novel sequence variants or characterizing tissue-specific expression patterns in research settings.

Working applications include western blot of whole-cell and mitochondrial lysates, together with immunohistochemistry on formalin-fixed paraffin-embedded sections. Aliquot upon first opening, store refrigerated, and protect from repeated freeze-thaw cycles to preserve antibody activity. For research use only; not intended for diagnostic procedures.