Anti-AKR1C3 Antibody

This rabbit polyclonal antibody from Antibodies.com targets AKR1C3 (Aldo-Keto Reductase Family 1 Member C3), a cytosolic NADPH-dependent oxidoreductase that plays central roles in steroid hormone and prostaglandin metabolism. The enzyme converts androstenedione to testosterone and estrone to estradiol, and also catalyzes prostaglandin F2α formation, linking it to androgen- and estrogen-dependent signaling in reproductive and endocrine tissues.

Validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human samples, the reagent is supplied as an unconjugated antiserum in a 100 µl volume, enabling direct labeling or signal amplification chemistries. Polyclonal reactivity across multiple epitopes of the AKR1C3 protein supports detection of full-length isoforms in cell lysates and tissue sections where AKR1C3 expression is being investigated as a biomarker or therapeutic target.

Researchers studying hormone-dependent cancers such as prostate, breast, and endometrial tumors, benign prostatic hyperplasia, and prostaglandin-driven inflammation pathways commonly apply this antibody to map enzyme distribution, characterize overexpression in clinical specimens, or confirm knockdown and knockout phenotypes at the protein level in cell-based models.