Anti-AKAP1 Antibody

This unconjugated polyclonal reagent from Antibodies.com is raised in rabbit and binds the human AKAP1 protein (A-kinase anchoring protein 1, also known as AKAP149 and D-AKAP1), a scaffold that tethers protein kinase A and other signaling molecules to the outer mitochondrial membrane. The antibody is supplied as 100 µl of antiserum suitable for western blot, immunohistochemistry, and immunofluorescence workflows on human samples.

AKAP1 organizes compartmentalized cAMP/PKA signaling at mitochondria and influences mitochondrial dynamics, apoptosis, and steroid hormone biosynthesis in tissues such as adrenal cortex, gonads, and liver. Researchers studying metabolic regulation, mitochondrial biology, or compartmentalized PKA anchoring use this reagent to detect endogenous AKAP1 in cell lysates and fixed tissue sections.

The product is presented unconjugated for direct detection with secondary antibodies of the user's choice and is reactive against human AKAP1, supporting immunoblotting, immunostaining of cultured cells and tissue, and subcellular localization studies of mitochondrial signaling complexes.