Anti-AK2 Antibody

This rabbit polyclonal reagent targets adenylate kinase 2 (AK2), a mitochondrial matrix enzyme that catalyzes the reversible transfer of a phosphate group between ATP and AMP. By supporting nucleoside interconversion and maintaining adenine nucleotide balance within mitochondria, AK2 contributes to oxidative phosphorylation coupling and overall cellular energy homeostasis. Researchers investigating mitochondrial bioenergetics, reticular dysgenesis, and combined immunodeficiency mechanisms routinely use this type of polyclonal reagent in their experimental workflows.

The unconjugated antibody from Antibodies.com is intended for Western blot (WB) and immunohistochemistry (IHC) workflows, with cross-reactivity demonstrated against Human, Mouse, and Rat samples. The unconjugated format allows flexible pairing with secondary reporters of the researcher's choice, including HRP-, biotin-, or fluorophore-conjugated anti-rabbit IgGs depending on the application platform.

Supplied as 100 µl of liquid at 1 mg/ml in a PBS buffer containing 0.1% sodium azide and 50% glycerol as a cryoprotectant, the formulation supports stable freezer storage while sodium azide prevents microbial contamination in working aliquots.

Because AK2 functions as a homodimer within the mitochondrial matrix, Western blot detection typically produces a band near the expected molecular weight, and IHC labeling yields a cytoplasmic and mitochondrial distribution pattern consistent with AK2's known subcellular localization.