Anti-Aire Antibody

The Anti-Aire Antibody from Antibodies.com is a rabbit polyclonal reagent raised against the Autoimmune Regulator (Aire) protein, a nuclear transcription factor best known for driving promiscuous expression of tissue-restricted antigens within medullary thymic epithelial cells (mTECs). This unconjugated IgG reagent recognises mouse Aire and is supplied as a 100 ug liquid aliquot in a single vial, validated for western blot and immunocytochemistry workflows. Investigators studying central immune tolerance, negative selection of autoreactive T cells, and mouse models of APECED syndrome can use it to detect endogenous Aire in thymic tissue sections, cultured mTEC lines, and nuclear extracts. For best results, store the vial at -20 degrees C, refrigerate working dilutions at 2-8 degrees C, and aliquot before use to limit freeze-thaw cycles and preserve polyclonal antibody activity.