Anti-AGA Antibody

Target a lysosomal amidase central to N-linked glycoprotein catabolism with this rabbit polyclonal Anti-AGA reagent from Antibodies.com, supplied as 100 µl of unconjugated antiserum. The IgG fraction supports detection of endogenous aspartylglucosaminidase in human and mouse samples by western blot and immunohistochemistry, providing a practical tool for studies of glycoprotein turnover and lysosomal function.

As a lysosomal hydrolase, AGA cleaves asparagine-linked glycopeptides during normal glycoprotein degradation. Loss-of-function variants in the AGA gene on chromosome 4q34 underlie aspartylglucosaminuria, a progressive lysosomal storage disorder, so this antibody is frequently used in research characterizing AGA expression, trafficking, and residual enzymatic activity in patient-derived cells and corresponding mouse models.

Because the reagent is unconjugated, it pairs freely with HRP-, biotin-, or fluorophore-conjugated secondary antibodies to suit chromogenic, fluorescent, or chemiluminescent workflows. For stability, aliquot the 100 µl volume upon receipt and store at -20 °C, avoiding repeated freeze-thaw cycles.