Anti-Adrenergic Receptor α-2A Antibody

Raised in rabbit, this unconjugated polyclonal antibody from Antibodies.com binds the α-2A adrenergic receptor (ADRA2A), a Gi/Go-coupled GPCR that mediates cellular responses to catecholamines such as epinephrine and norepinephrine. Supplied as 100 µl of ready-to-titer reagent, the antibody is validated for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples.

Researchers apply this reagent in neuroscience, cardiovascular, and metabolic studies to map receptor distribution in regions including the locus coeruleus, prefrontal cortex, and spinal cord, as well as in peripheral tissues such as vascular smooth muscle, pancreatic islets, and platelets. Because α-2A receptors inhibit adenylate cyclase and suppress presynaptic firing, they are widely investigated as targets in hypertension, sedation, analgesia, and glucose homeostasis research. Polyclonal reactivity provides flexible epitope recognition and supports comparative work across rodent models and human tissue specimens. Aliquot upon arrival to limit freeze-thaw cycles and preserve lot-to-lot performance across multiple experiments; refrigerated storage between uses is recommended.