Anti-ADRA1B Antibody

The Alpha-1B adrenergic receptor (ADRA1B) belongs to the G protein-coupled receptor superfamily, where it couples primarily through Gq to activate phospholipase C and trigger intracellular calcium mobilisation in response to catecholamine binding. This Antibodies.com rabbit polyclonal IgG reagent targets ADRA1B for Western Blot detection in human, mouse, and rat samples, supplied as 100 µl of unconjugated antibody ready to incorporate into standard immunoblotting workflows.

ADRA1B contributes to smooth muscle contraction, vascular tone regulation, and central nervous system signalling, and is studied in cardiovascular, neuropharmacological, and receptor-biology contexts. The polyclonal format recognises multiple epitopes across the receptor, supporting consistent visualisation of the endogenous protein in tissue lysates, membrane preparations, and cultured cell extracts during western blot analysis of expression changes, receptor desensitisation, or downstream GPCR pathway activity.

Cross-species reactivity against human, mouse, and rat orthologues enables comparative experiments in disease models, while the unconjugated IgG format permits pairing with HRP-, alkaline phosphatase-, or fluorophore-conjugated secondary antibodies depending on detection preference. For handling, the 100 µl aliquot should be stored at -20°C in working volumes to limit freeze-thaw cycles and preserve activity across multiple blotting experiments.