Anti-ADORA3 Antibody

The adenosine A3 receptor (ADORA3) is a G-protein coupled receptor (GPCR) that mediates cellular responses to extracellular adenosine, with established roles in inflammatory signalling, mast-cell regulation, and cardiac ischaemia-reperfusion injury. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com was raised against an internal region of human ADORA3 and is antigen affinity purified, selectively detecting the receptor at its expected molecular weight of approximately 36 kDa. The preparation is supplied as a 50 µl vial and has been validated for western blot (WB) and immunohistochemistry (IHC) workflows. Reactivity has been confirmed against Human, Mouse, and Rat samples, supporting comparative studies of adenosine-driven pathways across species. Researchers use this reagent to profile ADORA3 expression in tumour microenvironments, map receptor distribution in formalin-fixed tissue biopsies, characterise mast-cell and eosinophil activation, and probe receptor upregulation during inflammatory challenge. Because the antibody is unconjugated, it can be paired with HRP, biotin, or fluorescent secondary detection chemistries for chromogenic, immunofluorescence, or proximity ligation workflows. The reagent is stored at -20 °C and tolerates single-use aliquoting to minimise freeze-thaw cycles and preserve activity across multiple experimental sessions. For research use only; not intended for diagnostic or therapeutic applications.