Anti-ADO Antibody

ADO (2-aminoethanethiol dioxygenase), also annotated as C10orf22, is a non-heme iron-dependent thiol dioxygenase that oxidizes cysteamine to hypotaurine within the cysteine catabolic pathway and contributes to cellular thiol-redox homeostasis. This rabbit polyclonal reagent from Antibodies.com recognizes the human and mouse ADO protein and is supplied as 100 µl of unconjugated antiserum for western blot and immunohistochemistry workflows. Endogenous ADO can be detected in whole-cell lysates and in formalin-fixed paraffin-embedded tissue sections, supporting investigations of sulfur metabolism, oxidative stress signaling, and tumor biology, in which altered ADO expression has been described in breast carcinoma and selected other malignancies. Polyclonal reactivity broadens epitope coverage across the ADO primary sequence, and the unconjugated format lets researchers pair the antibody with their preferred horseradish peroxidase or fluorophore-conjugated secondary reagents and chromogenic detection chemistries. For handling, the vial should be kept at -20 °C in working aliquots to limit freeze-thaw exposure and preserve long-term performance across multiple experiments.