Anti-Adenosine A3-R Antibody

This rabbit polyclonal antibody from Antibodies.com targets the human Adenosine A3 receptor (ADORA3), a Gi-coupled G-protein coupled receptor that modulates cAMP signaling through adenylate cyclase inhibition. Raised in rabbit hosts and supplied as an unconjugated preparation in a 100 µl vial, the reagent is validated for Western blot (WB), immunohistochemistry (IHC), immunofluorescence (IF), and ELISA workflows on human samples.

Adenosine A3-R is actively investigated as a therapeutic and research target in inflammation, cancer biology, ischemic-reperfusion injury, and respiratory pathophysiology, where receptor expression patterns correlate with disease state and pharmacological response. Researchers use this polyclonal reagent to map ADORA3 distribution in tissue sections, monitor receptor upregulation in cultured cells, and probe downstream Gi-coupled signaling events, with demonstrated reactivity specific to the human receptor.

Polyclonal antibody vials benefit from aliquoting to limit freeze-thaw cycles; short-term storage is typically refrigerated, freezing is recommended for longer retention, and protection from light preserves antibody activity. The polyclonal format offers epitope diversity, supporting detection of the receptor across native conformations and diverse assay contexts, from fixed-cell imaging to detergent-solubilized Western blots.