Anti-ADCY4 Antibody

Targeting the ADCY4 enzyme (Adenylate Cyclase Type 4), this polyclonal antibody from Antibodies.com binds the membrane-associated adenylyl cyclase that converts ATP into cyclic AMP during G-protein-coupled receptor signaling. The reagent is raised in rabbit, supplied as an IgG preparation in unconjugated form, and validated specifically for Western Blot (WB) detection of endogenous ADCY4 in human and rat sample lysates.

The antibody is provided in a 50 µl volume, supporting multiple Western Blot experiments across different sample preparations. As an unconjugated primary reagent, it is compatible with many secondary antibodies and detection chemistries, offering flexibility across diverse Western Blot protocols and membrane chemistries.

ADCY4 participates in cAMP-mediated signal transduction across various tissues, with notable expression in the central nervous system and olfactory epithelium where it contributes to odorant-evoked signaling cascades. Researchers investigating adenylate cyclase isoforms, cAMP signaling dynamics, or GPCR-coupled pathways can use this reagent to examine ADCY4 expression and regulation. The antibody recognizes both human and rat orthologs, supporting comparative studies across these two species.