Anti-ACVR1C Antibody

Supplied by Antibodies.com as a 100 µl vial at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, this unconjugated rabbit polyclonal reagent targets ACVR1C (also known as ALK7) and is validated for Western blot and immunohistochemistry workflows across human, mouse, and rat samples. The reagent supports studies of TGF-beta superfamily signaling in metabolic and developmental research contexts.

ACVR1C functions as a type I serine/threonine kinase receptor that partners with type II receptors to propagate signals from activin B, activin AB, and GDF3 ligands. Researchers use polyclonal anti-ACVR1C reagents to interrogate receptor expression in pancreatic islets, adipose tissue, hypothalamus, and reproductive tissues, where ALK7 has been implicated in glucose homeostasis, adipocyte differentiation, and cell cycle regulation. The rabbit host and polyclonal format allow recognition of multiple epitopes on the target protein, which is useful when probing denatured lysates in Western blot or fixed tissue sections in IHC.

The 50% glycerol cryoprotectant allows short-term handling at -20 °C without freezing solid, while long-term archives are best kept at -80 °C to preserve binding activity. Aliquoting upon first use helps limit freeze-thaw cycles. Intended for research use only.