Anti-ACVR1B Antibody

Raised in rabbit, this unconjugated polyclonal reagent targets the Activin A receptor type 1B (ACVR1B), a type I serine/threonine kinase of the TGF-beta superfamily that transduces signals initiated by activin, Nodal, and related growth/differentiation factors via phosphorylation of SMAD2 and SMAD3. The reagent is supplied by Antibodies.com as 100 µL of antisera in a vial, validated for western blot and immunohistochemistry on formalin-fixed sections, and cross-reacts with mouse, rat, and human ACVR1B.

ACVR1B expression is commonly explored in studies of reproductive axis regulation, embryonic patterning, and pituitary adenoma biology, where somatic loss-of-function mutations in the receptor gene have been documented. The unconjugated format allows the laboratory to conjugate the primary reagent to a reporter of choice, and the polyclonal nature broadens epitope coverage across the kinase domain. For handling, store refrigerated and protect from repeated freeze-thaw cycles to preserve antibody activity.