Anti-ACTR3 Antibody

ACTR3 (Actin-Related Protein 3) is the catalytic ARP3 subunit of the seven-subunit ARP2/3 complex, generating branched actin filament networks that drive lamellipodia protrusion, endocytic trafficking, and directed cell migration. Distributed by Antibodies.com as a 100 µL vial of unconjugated rabbit polyclonal antiserum at 1 mg/mL in PBS with 0.1% Sodium Azide and 50% glycerol, the reagent is validated for Western blot (WB) and immunohistochemistry (IHC) detection of endogenous ACTR3 in Human, Mouse, and Rat samples.

Common research contexts for this antibody include studies of Arp2/3-dependent actin remodeling during neuronal development, immune synapse assembly at T-cell interfaces, invadopodia dynamics in metastatic cancer models, and pathogen-driven motility processes such as Listeria comet-tail formation. The polyclonal format provides broad epitope coverage across the ACTR3 sequence, supporting robust signal in whole-cell lysates, frozen tissue sections, and formalin-fixed paraffin-embedded (FFPE) specimens. To preserve activity, store refrigerated; aliquot on first use to avoid repeated freeze-thaw cycles, and handle the glycerol-stabilized solution using standard cold-chain precautions.