Anti-ACTL6B Antibody

This unconjugated polyclonal reagent from Antibodies.com targets ACTL6B (BAF53b), the actin-related subunit of the neuronal BAF (nBAF) SWI/SNF chromatin remodeling complex. Supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the 100 µl format supports western blot, immunohistochemistry, and immunofluorescence experiments in human, mouse, and rat samples. ACTL6B drives activity-dependent dendritic arborization and postmitotic neuronal maturation, and the antibody is widely used to characterize loss-of-function models linked to intellectual disability and developmental and epileptic encephalopathy. The polyclonal design gives broader epitope recognition than a monoclonal, which is useful when screening patient-derived truncating variants or validating CRISPR-edited neuronal lines. Aliquot on receipt and store frozen to minimize freeze-thaw cycles and preserve binding activity.