Anti-Active regulator of SIRT1 Antibody

This polyclonal antibody from Antibodies.com is raised against AROS (Active Regulator of SIRT1), also known as RPS19BP1, a small nuclear and cytoplasmic binding partner of SIRT1 that stimulates its NAD+-dependent deacetylase activity. Because AROS modulates sirtuin-mediated pathways involved in chromatin regulation, stress response, and metabolic signaling, it is of interest in studies of transcriptional control, cellular senescence, and metabolic disease mechanisms.

Raised in rabbit and supplied as 100 µg of unconjugated polyclonal antibody in a single vial, the reagent is validated for Western blot and immunohistochemistry on human samples. The unconjugated format allows flexible pairing with HRP- or fluorophore-conjugated secondary antibodies and is compatible with chromogenic DAB staining as well as fluorescence imaging workflows.

Typical experimental uses include profiling AROS expression across cultured human cell lines and tissue sections, characterizing AROS-SIRT1 complex dynamics by co-immunoprecipitation, and investigating upstream regulators of sirtuin activity in oncology, neurobiology, and metabolic research. For handling, store at -20 °C in working aliquots, limit freeze-thaw cycles, and protect the vial from light to preserve binding performance across the reagent shelf life.