Anti-ACSS2 Antibody

Polyclonal antibodies targeting ACSS2 (Acyl-CoA Synthetase Short-Chain Family Member 2) are valuable tools for studying cellular acetate metabolism and acetyl-CoA biosynthesis. This unconjugated antibody from Antibodies.com is raised in rabbit and supplied as 100 µl of liquid in a vial. It is validated for Western blot (WB) and immunofluorescence (IF) workflows across human, mouse, and rat samples, supporting comparative studies in cancer metabolism, hypoxic acetate utilization, and histone acetylation research.

The enzyme ACSS2 converts acetate into acetyl-CoA, linking nutrient availability to energy production and chromatin modification. Researchers working on tumor microenvironments, where ACSS2 activity supports lipid synthesis and gene regulation under stress, rely on consistent detection of endogenous protein levels. Cross-species reactivity allows parallel investigation in rodent disease models and human cell lines, while the unconjugated format provides flexibility for custom labeling with secondary fluorophores or enzymes.

For best results, store the antibody refrigerated in small aliquots and protect from light. Centrifuge briefly before use and limit repeated freeze-thaw cycles to preserve affinity. This reagent is intended for research use only in in vitro applications and is not validated for diagnostic or therapeutic purposes.