Anti-ACSL4 Antibody

This rabbit polyclonal antibody recognizes ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4), a key enzyme that ligates long-chain polyunsaturated fatty acids to coenzyme A and governs phospholipid composition in mammalian cells. The unconjugated reagent from Antibodies.com is supplied as a 100 µL vial and is validated for Western blot and immunohistochemistry workflows on human samples.

ACSL4 has emerged as one of the most studied regulators of ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, and changes in its expression track closely with cellular sensitivity to that pathway. Investigators rely on this antibody to profile ferroptosis susceptibility across cancer cell lines, to monitor lipid metabolic rewiring after GPX4 manipulation, and to map ACSL4 distribution in tumor versus matched normal tissue.

Raised in rabbit, reactive against human antigen, and free of any conjugated reporter, the polyclonal reagent can be paired with HRP- or fluorophore-conjugated anti-rabbit IgG secondary reagents for detection in cell lysates, tissue sections, and organoid preparations. The unconjugated format keeps the antibody flexible for parallel labeling strategies within a single experimental program, from chromogenic IHC on patient-derived specimens to immunoblotting of whole-cell lysates.