Anti-ACMSD Antibody

From Antibodies.com, this rabbit polyclonal primary antibody recognizes human aminocarboxymuconate semialdehyde decarboxylase (ACMSD), a cytosolic enzyme that directs 2-amino-3-carboxymuconate semialdehyde into the picolinic acid branch of the kynurenine pathway instead of the route leading to quinolinic acid and de novo NAD+ biosynthesis. Supplied as an unconjugated preparation in a 100 µL vial, the reagent is validated for Western blot and immunohistochemistry workflows and is intended for research use only.

ACMSD occupies a key metabolic branch point that influences whether tryptophan catabolites skew toward neuroprotective picolinic acid or neurotoxic quinolinic acid, which is why the enzyme is studied in neurodegeneration research, including Parkinson's disease models, as well as inflammation, hepatic NAD+ homeostasis, and tumor metabolism. As a polyclonal reagent raised in rabbit, the antibody recognizes multiple epitopes across the human ACMSD protein, useful for detecting conformational variants or partial proteolytic fragments in cell and tissue lysates. Aliquot upon first opening, protect from light, and avoid repeated freeze-thaw cycles to maintain performance across serial Western blot and IHC experiments.