Anti-ACKR3 Antibody

This polyclonal reagent from Antibodies.com targets ACKR3 (atypical chemokine receptor 3, also known as CXCR7 or RDC1), a non-classical GPCR that scavenges the chemokines CXCL12 and CXCL11 and contributes to cell migration, vascular development, cardiac cushion formation, and tumor progression across multiple cancer types. The antibody is raised in rabbit as polyclonal IgG, supplied unconjugated, and validated for Western blot and immunohistochemistry on human samples. Provided as 100 µl of liquid antiserum, it supports research into atypical chemokine signaling, retinal angiogenesis, and tumor microenvironment remodeling where aberrant ACKR3 expression has been documented. Investigators working in oncology, cardiovascular biology, or neuroscience apply the reagent to probe expression patterns in formalin-fixed paraffin-embedded tissue sections and protein lysates derived from human cell lines and primary tissue, enabling detection of endogenous receptor levels relevant to CXCR4/CXCR7 axis studies and disease-model investigations.