Anti-ACHE Antibody

Acetylcholinesterase (ACHE) terminates cholinergic signaling by hydrolyzing acetylcholine at synaptic clefts, and altered ACHE expression is implicated in neurodegenerative disease research, neuromuscular junction studies, and models of organophosphate toxicity. This rabbit polyclonal IgG from Antibodies.com was raised against ACHE and is supplied as a 50 µL aliquot of unconjugated antiserum, ready for use in immunohistochemistry workflows on mouse tissue.

The antibody specifically labels ACHE-expressing cholinergic neurons and motor endplates, supporting investigations of cholinergic pathway integrity, myasthenia gravis models, and developmental neurobiology. Storage at -20 °C in small aliquots is recommended to preserve activity across multiple freeze-thaw cycles; thaw on ice and centrifuge briefly before use. Researchers apply this reagent to fixed frozen or paraffin-embedded mouse brain, spinal cord, and skeletal muscle sections using standard IHC protocols with chromogenic or fluorescent detection.