Anti-ACE2 Antibody

Targeting Angiotensin-Converting Enzyme 2, this rabbit polyclonal reagent from Antibodies.com is a primary antibody supplied as 100 µl of unconjugated IgG, validated for Western Blot, Immunohistochemistry, and Flow Cytometry on human samples. ACE2 is a type I transmembrane zinc metallopeptidase that counters the pressor actions of angiotensin II by converting it to angiotensin 1-7, and it is also the cell-surface receptor exploited by SARS-CoV-1 and SARS-CoV-2 during viral entry. The polyclonal format recognizes multiple epitopes across the ACE2 ectodomain, which is useful when probing both full-length and shed soluble forms of the protein. Researchers use this antibody to map ACE2 expression in lung, kidney, heart, and intestinal tissues, to study renin-angiotensin signaling in cardiovascular models, and to characterize viral host-entry pathways. The unconjugated format allows flexible pairing with custom fluorophores, biotin, or HRP depending on the assay. Refrigerate upon arrival and aliquot to limit freeze-thaw cycles; this product is for research use only.