Anti-ACE Antibody

Affinity-purified rabbit polyclonal reagent from Antibodies.com raised against angiotensin-converting enzyme (ACE), the zinc metallopeptidase that cleaves angiotensin I into the potent vasoconstrictor peptide angiotensin II within the renin-angiotensin system. The unconjugated IgG preparation is supplied as a 200 µl liquid volume and is validated for western blot and immunohistochemistry on human, mouse, and rat specimens.

Laboratories apply this reagent to localize and quantify ACE expression in vascular endothelium, lung alveolar macrophages, renal proximal tubules, and cardiac tissue, and to probe experimental hypertension models studying ACE inhibitor pharmacology, salt-sensitive blood pressure regulation, and pulmonary capillary remodeling. The unconjugated format supports flexible detection chemistries, including pairing with HRP-conjugated, biotinylated, or fluorophore-labeled secondary antibodies.

Upon arrival, refrigerate the vial at 4°C for short-term use and prepare working aliquots for storage at -20°C. Avoid repeated freeze-thaw cycles to preserve the affinity-purified polyclonal population and the lot-to-lot reproducibility needed for consistent band intensity across biological replicates.