Anti-ACAT1 Antibody

Targeting the mitochondrial enzyme ACAT1, this rabbit polyclonal reagent from Antibodies.com is validated for western blot, immunohistochemistry, and immunofluorescence workflows across human, mouse, and rat samples. ACAT1 (acetoacetyl-CoA thiolase) catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA, serving as a key control point in ketone body biosynthesis and isoleucine catabolism. Loss-of-function mutations cause beta-ketothiolase deficiency, a rare autosomal recessive metabolic disorder, so the antibody is a relevant probe for investigations of mitochondrial energetics, fatty acid oxidation, and inherited metabolic disease. Supplied unconjugated in PBS with 0.1% sodium azide and 50% glycerol at 1 mg/ml, this 100 µl aliquot offers flexible multi-application use without prior conjugation, and the polyclonal format broadens epitope coverage across comparative tissue studies.