Anti-ABCG1 Antibody

The ABCG1 protein, a member of the ATP-binding cassette transporter G subfamily, mediates the efflux of cellular cholesterol and phospholipids to extracellular lipid acceptors such as HDL, supporting lipid homeostasis in macrophages and other tissues. This recombinant rabbit monoclonal antibody from Antibodies.com selectively recognizes an epitope on human and rat ABCG1, making it well-suited for studies of cholesterol metabolism, foam cell biology, and atherosclerosis-related pathways.

Validated for western blot (WB), immunocytochemistry/immunofluorescence (ICC/IF), and immunohistochemistry (IHC), the reagent supports detection of endogenous ABCG1 in cultured cells, frozen or formalin-fixed tissue sections, and membrane-enriched lysates. It is supplied as an unconjugated IgG in 100 µL per vial of TBS (pH 7.4) supplemented with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative, allowing flexible pairing with secondary antibodies or custom labeling strategies. Short-term storage at 4 °C is recommended for working aliquots, with longer-term storage at -20 °C to preserve activity.

Researchers investigating lipid transport disorders, macrophage cholesterol handling, or the cross-talk between ABCG1 and related transporters such as ABCA1 and ABCG4 will find this antibody useful for both qualitative localization and comparative protein expression analyses across human and rodent samples.