Anti-ABCC11 Antibody

Raised in rabbit against human ABCC11, this unconjugated polyclonal IgG antibody is supplied at a working volume of 50 µl and is validated for Western blot detection of the ABCC11 protein. ABCC11, also known as MRP8, belongs to the ATP-binding cassette (ABC) transporter superfamily and functions as an efflux pump for cyclic nucleotides, lipid analogs, and conjugated steroid sulfates. Tissue expression is most prominent in apocrine glands, breast, testis, and certain cancer cell lines, where altered ABCC11 activity has been linked to apocrine secretion, axillary odor phenotypes, and drug-resistance mechanisms in tumor cells.

Reactivity is restricted to human samples, making this reagent useful for studies investigating breast cancer biomarkers, MDR transporters, and metabolic secretion pathways. As an IgG preparation, the stock should be aliquoted to limit repeated freeze-thaw cycles and stored refrigerated in working volumes. Each vial is intended for single-use applications once opened and is provided unconjugated so it can be paired with HRP, fluorescent, or biotin labeling chemistries for downstream western blot imaging. Researchers evaluating transporter function, xenobiotic efflux, or genotype-phenotype associations of the earwax-type locus should find this polyclonal reagent a flexible tool for protein-level confirmation of ABCC11 expression, supplied by Antibodies.com.