Anti-ABCB7 Antibody

Produced in rabbit hosts and supplied at 200µl per vial, this unconjugated polyclonal IgG antibody recognizes the human ATP-binding cassette subfamily B member 7 (ABCB7) transporter, a mitochondrial inner membrane protein that mediates export of iron-sulfur cluster precursors to the cytosol. Validated for western blot (WB) and immunohistochemistry (IHC) workflows, the reagent supports studies of mitochondrial iron homeostasis and the biogenesis of cytosolic iron-sulfur proteins that depend on ABCB7 activity. The ABCB7 gene is linked to X-linked sideroblastic anemia with ataxia, making this antibody a useful reagent for investigators exploring how mutations in mitochondrial iron export machinery alter erythroid differentiation, neuronal function, and systemic iron balance. As an unconjugated format, the antibody gives laboratories flexibility to attach their own detection chemistry — HRP, biotin, or a fluorophore — for chromogenic IHC staining of tissue sections, immunoblotting of mitochondrial membrane fractions, or immunoprecipitation of native complexes. Each preparation from Antibodies.com is affinity-purified to limit non-specific background, providing a specific reagent for probing ABCB7 expression across human cell lines and primary tissue samples.