Anti-ABCA7 Antibody

ABCA7 is an ATP-binding cassette transporter most highly expressed in microglia and neurons, where it participates in lipid transport, phagocytic clearance of cellular debris, and cholesterol efflux to apolipoprotein acceptors. Loss-of-function variants in the gene have been repeatedly associated with increased risk of late-onset Alzheimer's disease in genome-wide studies, making ABCA7 a focal target for neurodegeneration and membrane-trafficking research. This unconjugated rabbit polyclonal antibody from Antibodies.com was raised against ABCA7 and is validated for Western blot on human, mouse, and rat samples. It is supplied as a 100 µl vial at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, supporting straightforward dilution into standard lysate buffers and chemiluminescent detection workflows. The reagent can be applied to probe endogenous ABCA7 levels in brain tissue, immortalized cell lines, and primary microglial preparations.