Anti-A2M Antibody

Alpha-2-Macroglobulin (A2M) is a large tetrameric plasma glycoprotein that acts as a broad-spectrum serine protease inhibitor, trapping target proteases through its bait region and clearing them via receptor-mediated endocytosis. This unconjugated polyclonal reagent from Antibodies.com is raised in rabbit and supplied at 1 mg/ml in phosphate-buffered saline with 0.05% sodium azide at approximately pH 7.6, in a 100 µl vial sized for multiple immunoblotting experiments.

The antibody recognizes the A2M target in human, mouse, and rat samples, supporting comparative studies of protease regulation across these species. Validated for western blot detection, it allows visualization of the full-length protein in tissue homogenates, cell lysates, conditioned media, or serum-depleted preparations. Common research contexts include hepatic protein synthesis, coagulation balance, acute-phase inflammation, and neurodegenerative conditions such as Alzheimer's disease, where A2M has been investigated as a binding carrier for amyloid-β.

The unconjugated format lets users pair this primary antibody with their own HRP- or fluorophore-conjugated secondary reagents, and the elevated starting concentration supports dilution series used to optimize signal-to-noise across different lysate preparations.