Anti-60S acidic ribosomal protein P1 Antibody

This Antibodies.com polyclonal reagent is raised in rabbit against 60S acidic ribosomal protein P1 (RPLP1), a phosphoprotein component of the large 60S ribosomal subunit that forms the ribosomal stalk complex together with P0 and P2 proteins. RPLP1 contributes to translation elongation by anchoring elongation factors at the GTPase center of the ribosome, making it a useful marker for studies of protein synthesis, ribosome biogenesis, and cellular stress responses.

The unconjugated antibody is validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human samples and is supplied as 100 ug of purified IgG per vial, enough material for dozens of blots or staining runs depending on dilution. As a polyclonal reagent, it targets multiple epitopes across the RPLP1 sequence, increasing the likelihood of detecting the protein even if one epitope is masked by post-translational modification or partial proteolysis.

Beyond its fundamental role in translation, RPLP1 is clinically relevant as part of the ribosomal P autoantigen complex recognized by autoantibodies in systemic lupus erythematosus and other connective tissue diseases. Researchers investigating autoimmunity, ribosomopathies, or translational control in cancer cells will find this reagent a versatile tool for both protein detection and immunolocalization studies.