Anti-4E-BP1 (N63) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically targets 4E-BP1 (eukaryotic translation initiation factor 4E-binding protein 1), a key downstream effector of mTOR signaling that regulates cap-dependent translation by sequestering eIF4E. The N63 designation refers to the immunogen used to generate the polyclonal reagent, which recognizes an epitope mapping to the N-terminal region of the human protein.

Supplied as 50 µl of unconjugated antibody at 1 mg/ml in phosphate buffered saline (approximately pH 7.2) with 0.05% sodium azide as a preservative. Validated for western blot and immunohistochemistry on human, mouse, and rat samples, the reagent supports studies of mTOR pathway activity, translational control, and signaling relevant to cancer biology, metabolic regulation, and neuroscience research.

For handling, refrigerate the vial upon arrival and aliquot into working volumes to limit freeze-thaw cycles; for extended storage, freeze at -20°C and protect from light. The polyclonal mix provides recognition of multiple epitopes on the ~20 kDa target, supporting reproducible band detection across WB membranes and IHC sections.