Anti-4E-BP1 Antibody

Raised in rabbit against the translational repressor 4E-BP1, this unconjugated polyclonal antibody from Antibodies.com is supplied as 100 µl of ready-to-use reagent validated for western blot, immunohistochemistry, and ELISA workflows on human, mouse, and rat samples.

4E-BP1 (eIF4E-binding protein 1) sits at the heart of mTORC1-regulated cap-dependent translation, sequestering the initiation factor eIF4E until it is phosphorylated at Thr37/46, Thr70, and Ser65. Loss of this brake through hyperphosphorylation is a recurring finding in tumor biology, metabolic disease research, and studies of autophagy and cell growth control, which is why the target recurs so often in signaling and oncology publications.

Each vial ships unconjugated at a working volume suitable for routine immunoblotting of phospho- and total-4E-BP1 bands, IHC staining of tissue sections, and ELISA-based quantification. For best results, aliquot on first thaw to limit freeze-thaw cycles and store refrigerated between uses.