Anti-26S proteasome non-ATPase regulatory subunit 11 Antibody

This rabbit polyclonal antibody from Antibodies.com recognizes the human 26S proteasome non-ATPase regulatory subunit 11 (PSMD11), a metalloprotease component of the 19S regulatory particle lid subcomplex. Its JAMM/MPN+ domain provides the deubiquitinating activity that removes ubiquitin chains from substrates immediately before they enter the 20S catalytic core for proteolysis, making it a central element of ubiquitin-dependent protein turnover and cellular protein quality control.

The reagent is supplied as 100 µg of unconjugated antibody in a vial, raised in rabbit and affinity-purified for polyclonal reactivity against the human target. Validated applications cover western blot analysis of cell lysates and immunohistochemistry on fixed tissue sections, supporting studies of proteasome assembly, neurodegenerative disease models, and cancer pathways where dysregulated proteasomal degradation has been implicated. Researchers investigating Rpn11 function, lid subcomplex integrity, or substrate deubiquitination can use this antibody to monitor endogenous protein levels across human cell lines and primary tissue samples.