Anti-14-3-3z (Ab-58) Antibody

Produced in rabbit as an unconjugated polyclonal reagent from Antibodies.com, this 50 µl antibody is validated for Western blot and immunohistochemistry on human, mouse, and rat samples.

14-3-3ζ is a conserved adapter protein that binds phosphoserine- and phosphothreonine-containing motifs on hundreds of client polypeptides, shaping pathways controlling cell-cycle progression, apoptosis, and intracellular signaling. Reagents such as this are commonly used to track expression and interaction partners in cell lysates and in fixed tissue sections.

Because the antibody is supplied unconjugated in a single-use vial, end users can couple it to HRP, biotin, or a fluorophore of choice, or apply it directly in chromogenic and fluorescence workflows. Long-term storage frozen in working aliquots helps preserve activity and limit freeze-thaw cycles, and the accompanying datasheet provides recommended starting dilutions for each application.

Reactivity is confirmed in human, mouse, and rat, supporting studies in neuroscience, oncology, and metabolic research where 14-3-3ζ dysregulation has been linked to disease mechanisms. Each lot is quality-controlled for specificity, and the reagent is intended for research use only.