Anti-14-3-3z (Ab-58) Antibody

Affinity-purified polyclonal reagent from Antibodies.com raised in rabbit against 14-3-3 zeta, a ~28 kDa adapter protein of the conserved 14-3-3 family encoded by the YWHAZ gene. Supplied as 100 µl of unconjugated liquid, this reagent is validated for Western blot and immunohistochemistry on human, mouse, and rat samples.

The 14-3-3 zeta isoform functions as a phosphoserine/phosphothreonine-binding scaffold that regulates signaling pathways controlling cell cycle progression, apoptosis, and metabolic adaptation, making isoform-resolved detection valuable for studies of cellular stress responses, neuronal development, and oncogenic signaling. The polyclonal format allows recognition of multiple epitopes across the target, an advantage when probing for isoform-specific expression patterns or when working with samples that may show post-translational modification heterogeneity. Recommended storage at -20 °C in working aliquots helps preserve reagent activity across repeated freeze-thaw cycles.