Anti-14-3-3 ζ Antibody

This rabbit polyclonal antibody recognizes the 14-3-3 ζ (zeta) regulatory protein, encoded by the YWHAZ gene, which acts as a phosphorylation-dependent scaffold in eukaryotic cells. 14-3-3 ζ binds phosphoserine and phosphothreonine motifs on client proteins, coordinating intracellular pathways that govern signal transduction, cell cycle progression, apoptosis, and cellular stress response. The unconjugated reagent, supplied by Antibodies.com as a 100 µl volume, is validated for Western blot, immunohistochemistry, immunoprecipitation, immunofluorescence, and ELISA workflows across human, mouse, and rat samples. Because the zeta isoform is one of the most abundant and broadly expressed 14-3-3 paralogs in mammalian tissue, this antibody is widely applied in studies of neuronal signaling, metabolic regulation, and cancer biology. The polyclonal format offers multi-epitope recognition of the target, supporting detection of the protein in whole-cell extracts, fixed tissue sections, and immunoprecipitated complexes.