Anti-11β-HSD1 Antibody

This rabbit polyclonal antibody targets 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), a NADPH-dependent microsomal enzyme that catalyzes the intracellular reduction of cortisone to the active glucocorticoid cortisol. The unconjugated reagent is supplied as 100 µl in a vial and is applied in Western blot, immunohistochemistry, and ELISA workflows across human, mouse, and rat sample sets. Researchers studying glucocorticoid metabolism, adipose tissue biology, hepatic gluconeogenesis, and metabolic disease use this reagent to assess 11β-HSD1 expression in liver, adipose, and central nervous system tissues. For long-term integrity, aliquot the antibody and store at -20°C, avoiding repeated freeze-thaw cycles. Antibodies.com raises the polyclonal antibody in rabbit host, delivering detection of the endogenous enzyme without a conjugated reporter so the reagent can be paired with HRP-, fluorophore-, or biotin-labeled secondary antibodies of the user's choice.