Anacardic Acid, 1 mg

STEMCELL Technologies supplies Anacardic Acid as a laboratory chemical for research use. The substance is the 6-alkyl salicylic acid 2-hydroxy-6-pentadecylbenzoic acid (CAS No. 16611-84-0) and is provided as a crystalline solid. According to the manufacturer's Safety Data Sheet, it is classified under the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) as Serious eye damage/eye irritation Category 2A, Skin sensitization Category 1, and Specific target organ toxicity (single exposure) Category 3. Listed hazard statements indicate that it causes serious eye irritation, may cause an allergic skin reaction, and may cause respiratory irritation.

Anacardic Acid is described as an epigenetic modifier that inhibits histone acetyltransferase (HAT) activity. Independent literature summarises it as an inhibitor of HAT-dependent transcription and protein SUMOylation, an activator of Aurora kinase A-mediated phosphorylation of Histone H3, and a suppressor of NF-κB activation and IκB-α phosphorylation at higher concentrations. The compound has a molecular weight of 348.5 and a molecular formula of C22H36O3. Reported solubilities from the Safety Data Sheet include DMF at 20 mg/mL, DMSO at 15 mg/mL, ethanol at 22 mg/mL, and ethanol:PBS (pH 7.2) at a 1:1 ratio of 0.5 mg/mL. The product is stable under recommended transport and storage conditions and is incompatible with strong oxidizing agents; hazardous decomposition products include carbon dioxide (CO2) and carbon monoxide. Recommended handling includes using protective gloves, eye protection, and face protection in a well-ventilated area.