All-Trans Retinoic Acid, 50 mg

STEMCELL Technologies supplies All-Trans Retinoic Acid (ATRA) as a crystalline solid reagent for use in research workflows. ATRA is a derivative of Vitamin A that functions as a ligand for the retinoic acid receptor (RAR), and acts as a retinoid pathway activator that activates both RAR and retinoid X receptor (RXR).

The Safety Data Sheet reports a molecular formula of C20H28O2 and a molecular weight of 300.4 (CAS 302-79-4), with a solubility of approximately 0.5 mg/mL in ethanol and approximately 20 mg/mL in DMF and DMSO. The substance is classified as a Skin corrosion/irritation Category 2 hazard and a Reproductive toxicity Category 1B hazard, with the hazard statements: causes skin irritation, and may damage fertility or the unborn child. It is also described as very toxic to aquatic life with long lasting effects. Listed synonyms include ATRA, NSC 122758, Retinoic acid, Trans retinoic acid, Tretinoin, and Vitamin A acid.

A California Proposition 65 warning applies: the compound is known to the State of California to cause birth defects or other reproductive harm. STEMCELL Technologies' Quality Management System is certified to ISO 13485, and the product is intended for research use only, not for human or animal diagnostic or therapeutic applications.