LNA-A(Bz) Amidite (250mg)

Locked Nucleic Acid (LNA) adenosine phosphoramidite supplied by QIAGEN as a 250 mg unit for incorporation into synthetic oligonucleotides. The Bz (benzoyl) protecting group on the N6 position of adenine makes this monomer compatible with standard solid-phase synthesis cycles, including detritylation, coupling, capping, and oxidation steps. Researchers use this monomer to design high-affinity antisense probes, allele-specific PCR primers, microRNA detection assays, and in situ hybridization probes, where the locked ribose conformation raises duplex melting temperature and improves mismatched discriminator recognition. The 250 mg format supports multiple synthesis scales, and the product ships in a sealed vial under inert atmosphere to protect the reactive phosphoramidite moiety from hydrolysis. Coupling efficiency is monitored amidite-by-amidite, and the monomer integrates cleanly with standard DNA, RNA, and other LNA phosphoramidites in mixed-backbone sequences used in antisense oligonucleotide research and nucleic acid therapeutic development.