Gatifloxacin, 1 g

A fluoroquinolone antibiotic supplied by STEMCELL Technologies as a laboratory chemical. Gatifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, and is identified by the chemical name 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 112811-59-3). Synonyms include AM 1155, BMS 206584-01, and PD 135432. The product is a crystalline solid with the molecular formula C19H22FN3O4 and a molecular weight of 375.4, and is supplied as 100% active substance. Reported solubility values are ~0.5 mg/mL in 1:1 DMF:PBS (pH 7.2) and ~10 mg/mL in DMF.

Gatifloxacin is classified as harmful if inhaled, swallowed, or in contact with skin (Acute Toxicity Category 4 for the inhalation, oral, and skin routes) and as a Category 1 respiratory and skin sensitizer. It may cause allergy or asthma symptoms or breathing difficulties if inhaled, and may cause an allergic skin reaction. The material is stable under normal conditions. Reported toxicological data include an oral TDLO in humans of 8.57 mg/kg, an intravenous TDLO in humans of 8.57 mg/kg, an oral TDLO in rabbits of 60 mg/kg/20M, an intravenous TDLO in rabbits of 20 mg/kg/5M, and an oral TDLO in mice of 175 mg/kg/7D (continuous). The product is not classified as dangerous goods for transport by DOT, ADR/RID, IMDG, or IATA, and carries a WHMIS classification of D1B (Toxic Material Causing Immediate and Serious Toxic Effects).

STEMCELL Technologies recommends storing the container tightly closed in accordance with the product insert. Users should avoid breathing dust or vapours, wear protective gloves, clothing, eye and face protection, and use respiratory protection where ventilation is inadequate. Spills should be contained and transferred to a chemical waste container for disposal in accordance with local regulations. In case of exposure, the affected person should be moved to fresh air, skin should be washed with soap and water for at least 20 minutes, eyes should be flushed with water, and medical attention sought; if swallowed, the mouth should be rinsed and a poison centre contacted.