Antisense LNA GapmeR ivr (5)

QIAGEN offers single-strand antisense oligonucleotides (ASOs) designed for effective RNA silencing of mRNA and lncRNA targets in cell culture and animal models. The design incorporates LNA technology to enable robust knockdown, working through RNase H-dependent degradation of the complementary RNA target. This mechanism supports specific gene silencing without RISC-related off-target activity, and the in vivo Ready grade allows uptake into cells without requiring a separate transfection reagent. Custom sequences can be conveniently designed through the Geneglobe site.

As an ASYT_ASSAY TECHNOLOGIES consumable within the QIAGEN portfolio, this LNA GapmeR is part of a series that includes Standard, Premium, in vivo Ready, and in vivo Large Scale grades, with options for phosphorothioate (PS) modification and labeling available with 3' and 5' FAM. The in vivo Ready grade offers ≥75% purity and supports purification via Na+ exchange, with options for HPLC purification and standard desalting.