Pepsinogen II (PGII) Antigen >90%

Pepsinogen II is a 40 kDa aspartic protease zymogen secreted by gastric chief cells and mucosal gland cells of the gastric corpus, where acidic gastric pH activates it into mature pepsin. The Antibodies.com antigen preparation is supplied as a lyophilized powder at >90% purity, packaged as 100 µg per vial and intended as an immunogen, plate-coating reagent, or assay standard for in vitro research workflows.

Validated for ELISA and Western blot applications, the reagent is suitable for assay development teams quantifying serum PGII, mapping epitope coverage of anti-PGII antibodies, or distinguishing PGII from the homologous pepsinogen I isoform during antibody characterization. Pepsinogen II is a clinically relevant gastric biomarker: serum PGII rises with Helicobacter pylori infection and gastric inflammation, while a depressed pepsinogen I/II ratio is associated with corpus atrophic gastritis and elevated gastric cancer risk, supporting its inclusion in non-invasive screening panels.

The lyophilized format supports refrigerated storage with extended shelf life, and researchers can reconstitute the antigen to working concentrations tailored to ELISA coating buffer or SDS-PAGE sample preparation.