Human Thyroglobulin

Purified Human Thyroglobulin from Antibodies.com is a 660 kDa homodimeric glycoprotein that serves as the biosynthetic precursor of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). This unconjugated protein is supplied as a 100 µg liquid preparation intended for use as an immunogen, plate-coating antigen, or assay standard in thyroid-related research workflows including ELISA calibration, Western blot, and immunohistochemistry applications.

Researchers studying differentiated thyroid carcinoma commonly employ human thyroglobulin to develop tumor marker assays, since circulating Tg measurement is a standard surveillance tool following thyroidectomy. The protein is also valuable for investigating Hashimoto's thyroiditis and Graves' disease, where anti-thyroglobulin autoantibodies are clinically relevant. Each vial should be stored at -20 °C in single-use aliquots to preserve iodination sites and prevent degradation; avoid repeated freeze-thaw cycles.

As a research-use-only reagent, this preparation supports in vitro studies of thyroid hormone biosynthesis, iodide organification, and autoimmune epitope mapping. Its native human sequence makes it a reliable reference material for generating monoclonal antibodies, validating mass spectrometry-based quantitation, and benchmarking immunoassay performance against clinical specimens.