Human Pro-GRP (Active)

The Human Pro-GRP (Active) protein from Antibodies.com is a recombinant preparation of the processed, bioactive form of pro-gastrin-releasing peptide, supplied as a 100 µg liquid aliquot in a single vial. Pro-GRP is the 125-amino-acid precursor that yields the 27-residue amidated GRP neuropeptide at its C-terminus, and the "active" designation refers to this C-terminal GRP-bearing region that engages the GRP/bombesin receptor (GRPR/BB2) with high affinity.

Clinically, circulating Pro-GRP is a recognised biomarker that distinguishes small cell lung carcinoma (SCLC) from non-small cell lung cancer and from benign pulmonary conditions, with serum concentrations frequently elevated in extensive-stage disease. Researchers use this recombinant standard to spike matrices, calibrate immunoassays, and run western blot, immunohistochemistry, and receptor-binding studies targeting the GRP/GRPR signalling axis in neuroendocrine tumour and lung cancer research applications.

For handling, store the unconjugated liquid preparation at -20 °C in working aliquots to limit freeze-thaw cycles, and avoid repeated exposure to room temperature. Intended for research use only; not for diagnostic or therapeutic procedures.