Human HBV PreS1 (Active)

The HBV pre-S1 protein supplied by Antibodies.com corresponds to the N-terminal extension of the Hepatitis B virus large surface antigen and is offered as a biologically active recombinant reagent. The pre-S1 domain contains the essential receptor-binding motif that mediates attachment of HBV and HDV to the hepatocyte entry receptor NTCP (sodium taurocholate cotransporting polypeptide, SLC10A1), making this region a focal point for viral entry studies and inhibitor screening.

Each vial contains 100 µg of unconjugated protein in liquid format, suitable for direct incorporation into ELISA, western blot, immunohistochemistry, and cell-based neutralization assays. Researchers routinely deploy recombinant pre-S1 as an immunogen for raising neutralizing antibodies, as a coating antigen for anti-preS1 titer measurement, and as a reference reagent for mapping B-cell epitopes relevant to therapeutic and prophylactic hepatitis B vaccine design.

For optimal stability, the protein should be stored frozen, aliquoted upon first use to limit freeze-thaw cycles, and handled on ice to preserve the conformational integrity of the NTCP-binding region.