Human DKK1 (Active)

Recombinant human DKK1 (Dickkopf-1) active protein supplied by Antibodies.com as a 1 mg liquid preparation in an unconjugated format. DKK1 is a secreted modulator of the canonical Wnt/β-catenin signaling cascade and plays key roles in bone metabolism, osteoblast differentiation, and embryogenesis. Aberrant DKK1 expression has been documented in multiple myeloma, hepatocellular carcinoma, and lung adenocarcinoma, making this reagent useful for cancer biology and bone disease research workflows.

The protein is supplied in a single vial and is recommended for functional assays including cell culture treatment, in vitro Wnt pathway modulation studies, and western blot standards. Store frozen at -80 °C in working aliquots to limit freeze-thaw cycles; avoid repeated freeze-thaw events to preserve biological activity. Briefly centrifuge before opening and handle using standard laboratory precautions.

Typical applications include receptor binding studies, inhibitor screening assays, and use as a reference standard in ELISA development targeting circulating DKK1 biomarkers.